Barbiturates
Barbiturates
CAS Number:
50-06-6
Batch Molecular Formula:
C12H12N2O3
Batch Molecular Weight:
232.235 g/mol
Physical Appearance:
Odourless White Crystalline Powder
Solubility:
Very Soluble in Water
Storage:
Store at RT
Barbiturates are a class of drugs derived from barbituric acid that act as central nervous system (CNS) depressants. Historically used for sedation, anesthesia, and treating seizures, they have largely been replaced by safer alternatives due to their high potential for overdose, dependence, and abuse.
Types of Barbiturates
1. By Duration of Action:
Ultra-Short-Acting:
Onset: Seconds to minutes; Duration: 15–30 minutes.
Used for anesthesia induction.
Examples: Thiopental, Methohexital.
Short-Acting:
Onset: 15–30 minutes; Duration: 3–4 hours.
Used as sedatives or pre-anesthetic agents.
Examples: Pentobarbital, Secobarbital.
Intermediate-Acting:
Onset: 30–60 minutes; Duration: 6–8 hours.
Historically used for anxiety or insomnia.
Example: Amobarbital.
Long-Acting:
Onset: 1 hour; Duration: 12–24 hours.
Primarily used for epilepsy.
Example: Phenobarbital.
2. Medical Formulation
Oral (tablets, capsules, solutions).
Injectable (intravenous or intramuscular).
Suppositories (less common).
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Effects
1. Therapeutic Effects
CNS depression leads to sedation, relaxation, and reduced anxiety.
At higher doses, induces sleep or anesthesia.
2. Side Effects
Common:
Drowsiness, dizziness, headache, and confusion.
Nausea, vomiting, and constipation.
Serious:
Respiratory depression.
Hypotension, bradycardia.
Dependence, tolerance, and withdrawal symptoms.
Usage
1. Medical Use
Seizure Control:
Long-acting barbiturates like phenobarbital are used for epilepsy.
Anesthesia:
Ultra-short-acting agents like thiopental are used for induction of anesthesia.
Severe Insomnia and Anxiety:
Occasionally used when other treatments fail (rare due to risks).
Euthanasia and Physician-Assisted Suicide:
In some countries or contexts, barbiturates are used in end-of-life care.
2. Non-Medical Use
Misused recreationally for their sedative and euphoric effects.
Commonly combined with alcohol or opioids, increasing overdose risks.
Disclaimer
Products falling in to controlled substance category / list of schedule drugs shall be exported directly from the manufacturer principals only against receipt of original import permission issued by concerned authorities of the importing country. Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer’s risk. Most OTC drugs are not reviewed and approved by FDA, however, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies. This is only for study not for any Human / Veterinary use. (Condition Apply)* Delphis Pharmaceutical India warns the buyers / importers not to use/sell/procure any goods to achieve a product which might be knowingly causing an infringement / controlled / banned drugs. Delphis Pharmaceutical India is not responsible or liable for the same.
